The aberrant expression and localization of prohibitin during apoptosis of human cholangiocarcinoma Mz‐ChA‐1 cells
Copyright policy )The aberrant expression and localization of prohibitin during apoptosis of human cholangiocarcinoma Mz‐ChA‐1 cells
In this study, we aimed to investigate the aberrant expression and shift in localization of prohibitin (PHB) during apoptosis of human cholangiocarcinoma cells. Our study demonstrated that PHB was expressed primarily in the cytoplasm and only a little in the nucleus. However, PHB expression significantly decreased, and its localization shifted from the cytoplasm to the nucleus during apoptosis. PHB co‐localized with AIF, Rb, p53, and c‐Fos, but the region of co‐localization was altered after treatment. Meanwhile, we detected a direct interaction between PHB and both p53 and Rb in Mz‐ChA‐1 cells. These results suggest that the altered localization and expression of PHB, as well as its co‐localization with related oncogenes and tumor suppressor genes, can affect the apoptosis of Mz‐ChA‐1 cells.
- Hebei University China (People's Republic of)
- State Key Laboratory of Cell Stress Biology China (People's Republic of)
- Henan University of Urban Construction China (People's Republic of)
- First Affiliated Hospital of Xiamen University China (People's Republic of)
- Xiamen University China (People's Republic of)
INDUCED DIFFERENTIATION, Localization shift, Cytoplasm, Interaction, Carcinogenesis, 610, Apoptosis, Human cholangiocarcinoma, Retinoblastoma Protein, Cholangiocarcinoma, Cell Line, Tumor, Prohibitins, Humans, TUMOR-SUPPRESSOR, CANCER CELLS, NUCLEAR-MATRIX, CARCINOGENESIS, PROLIFERATION, Apoptosis Inducing Factor, Genes, fos, FAMILY, Gene Expression Regulation, Neoplastic, Repressor Proteins, TARGET, Prohibitin, Tumor Suppressor Protein p53, RB, MITOCHONDRIAL PROTEINS
INDUCED DIFFERENTIATION, Localization shift, Cytoplasm, Interaction, Carcinogenesis, 610, Apoptosis, Human cholangiocarcinoma, Retinoblastoma Protein, Cholangiocarcinoma, Cell Line, Tumor, Prohibitins, Humans, TUMOR-SUPPRESSOR, CANCER CELLS, NUCLEAR-MATRIX, CARCINOGENESIS, PROLIFERATION, Apoptosis Inducing Factor, Genes, fos, FAMILY, Gene Expression Regulation, Neoplastic, Repressor Proteins, TARGET, Prohibitin, Tumor Suppressor Protein p53, RB, MITOCHONDRIAL PROTEINS
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