Loss of the F-BAR protein CIP4 reduces platelet production by impairing membrane-cytoskeleton remodeling
Copyright policy )Loss of the F-BAR protein CIP4 reduces platelet production by impairing membrane-cytoskeleton remodeling
Key PointsCIP4 affects the remodeling of both plasma membrane and cortical cytoskeleton in megakaryocytes. CIP4 in platelet biogenesis involves cortical tension, as does WASP, and WASP-independent plasma membrane reorganization.
- University of Toronto Canada
- Institut Gustave Roussy France
- Northwestern University United States
- University of Paris-Saclay France
- University of Washington United States
Blood Platelets, Male, Mice, Knockout, Ploidies, Membrane Fluidity, Cell Membrane, Biomechanical Phenomena, Cell Line, Colony-Forming Units Assay, Mice, Inbred C57BL, Minor Histocompatibility Antigens, Actin Cytoskeleton, Mice, Protein Transport, Gene Knockdown Techniques, Animals, Megakaryocytes, Microtubule-Associated Proteins, Cytoskeleton, Gene Deletion
Blood Platelets, Male, Mice, Knockout, Ploidies, Membrane Fluidity, Cell Membrane, Biomechanical Phenomena, Cell Line, Colony-Forming Units Assay, Mice, Inbred C57BL, Minor Histocompatibility Antigens, Actin Cytoskeleton, Mice, Protein Transport, Gene Knockdown Techniques, Animals, Megakaryocytes, Microtubule-Associated Proteins, Cytoskeleton, Gene Deletion
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