Evidence for Autoregulation of Cystathionine γ-Synthase mRNA Stability in Arabidopsis
Copyright policy )Evidence for Autoregulation of Cystathionine γ-Synthase mRNA Stability in Arabidopsis
Control of messenger RNA (mRNA) stability serves as an important mechanism for regulating gene expression. Analysis of Arabidopsis mutants that overaccumulate soluble methionine (Met) revealed that the gene for cystathionine γ-synthase (CGS), the key enzyme in Met biosynthesis, is regulated at the level of mRNA stability. Transfection experiments with wild-type and mutant forms of the CGS gene suggest that an amino acid sequence encoded by the first exon of CGS acts in cis to destabilize its own mRNA in a process that is activated by Met or one of its metabolites.
- Hokkaido Bunkyo University Japan
- Hokkaido University Japan
- Rutgers, The State University of New Jersey United States
Transcription, Genetic, Carbon-Oxygen Lyases, Molecular Sequence Data, Arabidopsis, Exons, Genes, Plant, Transfection, Gene Expression Regulation, Enzymologic, Kinetics, Methionine, Gene Expression Regulation, Plant, Genes, Reporter, Mutation, Amino Acid Sequence, RNA, Messenger, Sequence Alignment
Transcription, Genetic, Carbon-Oxygen Lyases, Molecular Sequence Data, Arabidopsis, Exons, Genes, Plant, Transfection, Gene Expression Regulation, Enzymologic, Kinetics, Methionine, Gene Expression Regulation, Plant, Genes, Reporter, Mutation, Amino Acid Sequence, RNA, Messenger, Sequence Alignment
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).164 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 1% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1%
Citations provided by BIP!Popularity provided by BIP!