Gene Expression of Endothelin Isoforms and Receptors in Endothelin-1 Knockout Mice
Copyright policy )Gene Expression of Endothelin Isoforms and Receptors in Endothelin-1 Knockout Mice
Gene expression of endothelin (ET) isoforms and receptors was examined in ET-1 knockout mice and compared with that of wild-type mice. ET-1 mRNA and peptide levels were in parallel with the number of Edn1 authentic alleles. ET-2 mRNA levels in intestine and ET-3 mRNA and/or peptide levels in lung, brain, and intestine were not different among Edn1+/+ wild-type, Edn1+/- heterozygous, and Edn1-/- homozygous mice. ET(A) and ETB receptor mRNA levels in several organs also were not different among Edn1+/+ wild-type, Edn1+/- heterozygous, and Edn1-/- homozygous mice. These results suggest that gene expression of ET-2, ET-3, and ET(A/B) receptors is not affected by levels of ET-1 production and is regulated independently. Neither compensation by redundant expression of other ET isoforms nor upregulation of ET receptors could explain the elevated blood pressure in Edn1+/- heterozygous mice.
- University of Tokyo Japan
Mice, Knockout, Mice, Mice, Inbred ICR, Receptors, Endothelin, Endothelins, Hypertension, Animals, Gene Expression, RNA, Messenger
Mice, Knockout, Mice, Mice, Inbred ICR, Receptors, Endothelin, Endothelins, Hypertension, Animals, Gene Expression, RNA, Messenger
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