Block of a subset of sodium channels exacerbates experimental autoimmune encephalomyelitis
Copyright policy )Block of a subset of sodium channels exacerbates experimental autoimmune encephalomyelitis
Voltage-gated sodium channels (Navs) are involved in several aspects of the pathogenesis of multiple sclerosis (MS). Within acute MS plaques, they are expressed along demyelinated axons. Studies in experimental autoimmune encephalomyelitis (EAE) demonstrated a neuroprotective effect of non-specific Nav blockers. Further, block of specific Navs involved in MS is suggested to have an advantage over non-specific blockers. We investigated the effects of the synthetic Midi peptide in EAE, as it potently and specifically blocks Nav1.2, Nav1.4 and Nav1.6. Administration of this Midi peptide worsens the clinical disease pattern and Nav1.2 and Nav1.6 expression levels were elevated in brain but not in spinal cord of Midi-treated mice, implicating that Navs play a complex role in the pathogenesis of EAE.
- Transnational University Limburg Belgium
- Transnational University Limburg Netherlands
- Katholieke Universiteit Leuven Belgium
- KU Leuven Belgium
- Hasselt University Belgium
Encephalomyelitis, Autoimmune, Experimental, NAV1.2 Voltage-Gated Sodium Channel, Chemistry Techniques, Synthetic, Peptide Fragments, Sodium Channels, Mice, Inbred C57BL, Mice, NAV1.6 Voltage-Gated Sodium Channel, Animals, Female, Cell Line, Transformed, Sodium Channel Blockers
Encephalomyelitis, Autoimmune, Experimental, NAV1.2 Voltage-Gated Sodium Channel, Chemistry Techniques, Synthetic, Peptide Fragments, Sodium Channels, Mice, Inbred C57BL, Mice, NAV1.6 Voltage-Gated Sodium Channel, Animals, Female, Cell Line, Transformed, Sodium Channel Blockers
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).11 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!