Drosophila SAP18, a member of the Sin3/Rpd3 histone deacetylase complex, interacts with Bicoid and inhibits its activity
Copyright policy )Drosophila SAP18, a member of the Sin3/Rpd3 histone deacetylase complex, interacts with Bicoid and inhibits its activity
Bicoid directs anterior development in Drosophila embryos by activating different genes along the anterior-posterior axis. However, its activity is down-regulated at the anterior tip of the embryo, in a process known as retraction. Retraction is under the control of the terminal polarity system, and results in localized repression of Bicoid target genes. Here, we describe a Drosophila homolog of human SAP18, a member of the Sin3A/Rpd3 histone deacetylase complex. dSAP18 interacts with Bicoid in yeast and in vitro, and is expressed early in development coincident with Bicoid. In tissue culture cells, dSAP18 inhibits the ability of Bicoid to activate reporter genes. These results suggest a model in which dSAP18 interacts with Bicoid to silence expression of Bicoid target genes in the anterior tip of the embryo.
- Thomas Jefferson University United States
- Wadsworth Center United States
- New York State Department of Health United States
- State University of New York at Potsdam United States
Homeodomain Proteins, Saccharomyces cerevisiae Proteins, Base Sequence, Sequence Homology, Amino Acid, Molecular Sequence Data, Autophagy-Related Proteins, Chromosome Mapping, Gene Expression Regulation, Developmental, RNA-Binding Proteins, DNA, Histone Deacetylases, Trans-Activators, Animals, Drosophila Proteins, Humans, Drosophila, Amino Acid Sequence, Carrier Proteins, Co-Repressor Proteins, Protein Binding
Homeodomain Proteins, Saccharomyces cerevisiae Proteins, Base Sequence, Sequence Homology, Amino Acid, Molecular Sequence Data, Autophagy-Related Proteins, Chromosome Mapping, Gene Expression Regulation, Developmental, RNA-Binding Proteins, DNA, Histone Deacetylases, Trans-Activators, Animals, Drosophila Proteins, Humans, Drosophila, Amino Acid Sequence, Carrier Proteins, Co-Repressor Proteins, Protein Binding
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