CD13-positive bone marrow-derived myeloid cells promote angiogenesis, tumor growth, and metastasis
Copyright policy )CD13-positive bone marrow-derived myeloid cells promote angiogenesis, tumor growth, and metastasis
Significance The progression of many solid tumors is associated with increased vascularization. We previously recognized involvement in tumor development and angiogenesis of tumor stromal cells expressing the CD13 protease aminopeptidase. The basic biological concept of participation of nontumor cells in the cancer stroma microenvironment is strengthened in the present study by our finding that a CD11b + CD13 + myeloid subset of bone marrow-derived cells affects pericyte biology and angiogenesis and thereby influences tumor growth and metastasis. Therapeutic implications of the identification of specific CD11 + CD13 + myeloid bone marrow-derived cells as participants in the mechanism of tumor angiogenesis merit further investigation.
- Dignity Health United States
- Harvard University United States
- The University of Texas MD Anderson Cancer Center United States
- Beth Israel Deaconess Medical Center United States
- Methodist Hospital United States
Mice, Knockout, Mice, Inbred BALB C, CD11b Antigen, Neovascularization, Pathologic, Bone Marrow Cells, Neoplasms, Experimental, CD13 Antigens, Mice, Cell Line, Tumor, Animals, Angiogenesis Inducing Agents, Myeloid Cells, Neoplasm Metastasis
Mice, Knockout, Mice, Inbred BALB C, CD11b Antigen, Neovascularization, Pathologic, Bone Marrow Cells, Neoplasms, Experimental, CD13 Antigens, Mice, Cell Line, Tumor, Animals, Angiogenesis Inducing Agents, Myeloid Cells, Neoplasm Metastasis
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