Developmental and Differential Regulations in Gene Expression of Xenopus Pleiotropic Factors-α and -β
Copyright policy )Developmental and Differential Regulations in Gene Expression of Xenopus Pleiotropic Factors-α and -β
Using conserved nucleotide sequences in mammalian osteoblast specific factor-1 (OSF-1) coding regions, we isolated two kinds of cDNA clones from the Xenopus brain library. The encoded proteins, named Xenopus pleiotrophic factors (X-PTFs)-alpha and -beta, were 65 and 87% homologous to human midkine and OSF-1, respectively. In the adult frog, X-ptf-alpha was expressed in the ovary, brain, eye, bone, heart and lung, whereas X-ptf-beta was expressed in the brain, eye and bone. By in situ hybridization of the tailbud embryo, X-ptf-alpha mRNA was detected rather broadly in the head/tail regions including the central nervous system (CNS), whereas X-ptf-beta mRNA was restricted to the CNS, particularly in the hind-brain. During embryogenesis, X-ptf-alpha mRNA was detected in the one-cell stage embryo, whereas only zygotic expression was observed in X-ptf-beta. X-ptf-beta mRNAs contained approximately 79 bp tandem repeats in the 3'-untranslated region, complementary to those found in retinoic acid cellular receptor mRNA and in the sense strand of short interspersed repeat transcripts in X. laevis.
Aging, Embryo, Nonmammalian, Base Sequence, Midkine, Molecular Sequence Data, Polymerase Chain Reaction, Mesoderm, Mice, Gene Expression Regulation, Organ Specificity, Animals, Cytokines, Humans, Cattle, Female, Amino Acid Sequence, Carrier Proteins, Growth Substances, Conserved Sequence, DNA Primers
Aging, Embryo, Nonmammalian, Base Sequence, Midkine, Molecular Sequence Data, Polymerase Chain Reaction, Mesoderm, Mice, Gene Expression Regulation, Organ Specificity, Animals, Cytokines, Humans, Cattle, Female, Amino Acid Sequence, Carrier Proteins, Growth Substances, Conserved Sequence, DNA Primers
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