Combination analysis of three polymorphisms for predicting the risk for steroid-induced osteonecrosis of the femoral head
Copyright policy )Combination analysis of three polymorphisms for predicting the risk for steroid-induced osteonecrosis of the femoral head
Osteonecrosis of the femoral head (ONF) often develops following corticosteroid administration. We previously investigated the genetic background for the development of corticosteroid-induced ONF and found relations between ONF development and genetic polymorphisms in the ATP binding cassette B1 (ABCB1) gene (C3435T), apolipoprotein B (ApoB) gene (C7623T), and cAMP-response element binding protein-binding protein (CBP) gene (rs3751845). In the present study, we examined whether combined information regarding these three single nucleotide polymorphisms (SNPs) in the ABCB1, ApoB, and CBP genes is useful for predicting ONF development.A case-control study was performed to study the development of corticosteroid-induced ONF. The cases were 34 patients who developed ONF, and the references were 123 patients who did not develop ONF. To evaluate the presence of interactions among the ABCB1, ApoB, and CBP genes, a synergistic index was calculated using an additive model.The synergistic index between the ABCB1 and CBP genes was >1.00 (1.99), revealing the presence of an interaction.Through analysis of multiple genes that may affect ONF development, we have shown a possible relation among genes encoding completely different proteins. We believe that analysis of the interactions among these genes can contribute to elucidating the mechanism of ONF development in addition to enabling identification of high-risk patients for ONF development.
- Kyoto Prefectural University of Medicine Japan
- Osaka University Japan
- Osaka Metropolitan University Japan
- Osaka Gakuin University Japan
Adult, Male, ATP Binding Cassette Transporter, Subfamily B, Middle Aged, CREB-Binding Protein, Polymorphism, Single Nucleotide, Young Adult, Gene Frequency, Femur Head Necrosis, Case-Control Studies, Odds Ratio, Humans, Female, Genetic Predisposition to Disease, Steroids, ATP Binding Cassette Transporter, Subfamily B, Member 1, Biomarkers, Apolipoproteins B
Adult, Male, ATP Binding Cassette Transporter, Subfamily B, Middle Aged, CREB-Binding Protein, Polymorphism, Single Nucleotide, Young Adult, Gene Frequency, Femur Head Necrosis, Case-Control Studies, Odds Ratio, Humans, Female, Genetic Predisposition to Disease, Steroids, ATP Binding Cassette Transporter, Subfamily B, Member 1, Biomarkers, Apolipoproteins B
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