Comparative analysis of the natriuretic peptide precursor gene cluster in vertebrates reveals loss of ANF and retention of CNP‐3 in chicken
Copyright policy )Comparative analysis of the natriuretic peptide precursor gene cluster in vertebrates reveals loss of ANF and retention of CNP‐3 in chicken
AbstractWe identified and characterized the chicken natriuretic peptide precursor gene cluster and found its organization to be highly conserved compared with the mammalian Nppb‐Nppa cluster. However, phylogenetic analysis indicated that the putative chicken natriuretic peptide precursor genes are the homologues of CNP‐3 and Nppb, respectively. Comparative expression analysis revealed that, in human, mouse, and rat hearts, Nppb is a novel marker for the differentiating working myocardium. Its expression pattern is strikingly similar to that of Nppa before birth, and diverges only after birth. In contrast, whereas the chicken Nppb gene expression profile resembled that of mammalian Nppb, the CNP‐3 gene showed very limited expression in the heart, not resembling the pattern of either Nppa or Nppb. These results show that, in chicken, the Nppa gene has been lost from the natriuretic peptide precursor gene cluster, whereas the CNP‐3 gene has been retained. Developmental Dynamics 233:1076–1082, 2005. © 2005 Wiley‐Liss, Inc.
- Amsterdam UMC Netherlands
- Wageningen University & Research Netherlands
- Amsterdam UMC, location AMC Netherlands
- Amsterdam UMC, location VUmc Netherlands
- University of Amsterdam Netherlands
CNP-3, Molecular Sequence Data, cloning, heart, Chick Embryo, differential expression, Avian Proteins, Evolution, Molecular, Mice, sequence-analysis, Animals, Humans, rat, Amino Acid Sequence, RNA, Messenger, Murine, mouse, Phylogeny, Phylogenetic analysis, Base Sequence, Myocardium, Computational Biology, Gene Expression Regulation, Developmental, Heart, Natriuretic Peptide, C-Type, atrial, cardiac chamber formation, Chicken, porcine brain, Rats, messenger-rna, ANF, BNF, Multigene Family, Gene expression, Cardiac, Chickens, Atrial Natriuretic Factor, Human
CNP-3, Molecular Sequence Data, cloning, heart, Chick Embryo, differential expression, Avian Proteins, Evolution, Molecular, Mice, sequence-analysis, Animals, Humans, rat, Amino Acid Sequence, RNA, Messenger, Murine, mouse, Phylogeny, Phylogenetic analysis, Base Sequence, Myocardium, Computational Biology, Gene Expression Regulation, Developmental, Heart, Natriuretic Peptide, C-Type, atrial, cardiac chamber formation, Chicken, porcine brain, Rats, messenger-rna, ANF, BNF, Multigene Family, Gene expression, Cardiac, Chickens, Atrial Natriuretic Factor, Human
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