FANCA and FANCC modulate TLR and p38 MAPK–dependent expression of IL-1β in macrophages
Copyright policy )FANCA and FANCC modulate TLR and p38 MAPK–dependent expression of IL-1β in macrophages
Key PointsTLR-activated FANCA- and FANCC-deficient macrophages overproduce IL-1β. IL-1β suppresses in vitro expansion of Fancc-deficient multipotent hematopoietic progenitor cells.
- OHSU Knight Cancer Institute United States
- Oregon Health & Science University United States
- Veterans Health Administration United States
Mice, Knockout, Fanconi Anemia Complementation Group A Protein, Inflammasomes, Reverse Transcriptase Polymerase Chain Reaction, Macrophages, Blotting, Western, Fanconi Anemia Complementation Group C Protein, Interleukin-1beta, Imidazoles, Intracellular Signaling Peptides and Proteins, Naphthalenes, Protein Serine-Threonine Kinases, Hematopoietic Stem Cells, Cell Line, Tumor, Animals, Humans, Pyrazoles, RNA Interference, Cells, Cultured, Cell Proliferation
Mice, Knockout, Fanconi Anemia Complementation Group A Protein, Inflammasomes, Reverse Transcriptase Polymerase Chain Reaction, Macrophages, Blotting, Western, Fanconi Anemia Complementation Group C Protein, Interleukin-1beta, Imidazoles, Intracellular Signaling Peptides and Proteins, Naphthalenes, Protein Serine-Threonine Kinases, Hematopoietic Stem Cells, Cell Line, Tumor, Animals, Humans, Pyrazoles, RNA Interference, Cells, Cultured, Cell Proliferation
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