An Id-related helix-loop-helix protein encoded by a growth factor-inducible gene.
Copyright policy )An Id-related helix-loop-helix protein encoded by a growth factor-inducible gene.
An mRNA encoding a helix-loop-helix protein that we have named HLH462 is induced in mouse 3T3 cells as part of the immediate early transcriptional response to growth factors and other signaling agents. The RNA is present in a number of mouse tissues and in the developing mouse fetus. The HLH462 gene has been mapped by interspecific backcross analysis to the distal region of mouse chromosome 4. In its helix-loop-helix region HLH462 is closely related to the Id protein and the Drosophila emc protein. Like Id, HLH462 lacks a basic region required for DNA binding, and it inhibits the DNA-binding activities of other helix-loop-helix proteins. On the basis of its structural and functional similarity to Id, we suggest that HLH462 may inhibit the activities of helix-loop-helix transcription factors during the cellular growth response and during development.
- University of Illinois at Chicago United States
- National Institutes of Health United States
- Johns Hopkins Medicine United States
- Johns Hopkins University United States
- Howard Hughes Medical Institute United States
Inhibitor of Differentiation Protein 1, Mice, Inbred BALB C, Base Sequence, Molecular Sequence Data, Proteins, DNA, Blotting, Northern, DNA-Binding Proteins, Repressor Proteins, Mice, Organ Specificity, Protein Biosynthesis, Sequence Homology, Nucleic Acid, Animals, Inhibitor of Differentiation Proteins, Amino Acid Sequence, RNA, Messenger, Cloning, Molecular, Cells, Cultured, Transcription Factors
Inhibitor of Differentiation Protein 1, Mice, Inbred BALB C, Base Sequence, Molecular Sequence Data, Proteins, DNA, Blotting, Northern, DNA-Binding Proteins, Repressor Proteins, Mice, Organ Specificity, Protein Biosynthesis, Sequence Homology, Nucleic Acid, Animals, Inhibitor of Differentiation Proteins, Amino Acid Sequence, RNA, Messenger, Cloning, Molecular, Cells, Cultured, Transcription Factors
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