Estrogen Receptors Alpha and Beta and the Risk of Open-angle Glaucoma
Copyright policy )Estrogen Receptors Alpha and Beta and the Risk of Open-angle Glaucoma
To investigate whether polymorphisms in the estrogen receptor alpha (ESR1) and beta (ESR2) genes were a risk factor for open-angle glaucoma (OAG).Participants 55 years and older from the population-based Rotterdam Study underwent, at baseline and at follow-up, the same ophthalmic examination, including visual field screening and stereo optic disc photography. A diagnosis of OAG was based on an algorithm using optic disc measures and visual field loss. Haplotypes of the ESR1 and ESR2 genes were determined.We diagnosed incident OAG in 87 of 3842 participants (2.3%) at risk after a mean follow-up of 6.5 years. We could not detect any association with ESR1 haplotypes. Haplotype 1 of ESR2 showed a 3.6-fold (95% confidence interval, 1.4-9.2) higher risk of incident OAG in men. In women, no association was found between ESR2 and incident OAG.Polymorphisms in the ESR1 gene are unrelated to OAG, but ESR2 polymorphisms seem to lead to increased risk of OAG in men.
- Amsterdam UMC Netherlands
- Erasmus University Rotterdam Netherlands
- University of Amsterdam Netherlands
- Royal Netherlands Academy of Arts and Sciences (KNAW) Netherlands
- Erasmus University Medical Center Netherlands
Male, Optic Disk, Estrogen Receptor alpha, Vision Disorders, Middle Aged, Polymorphism, Single Nucleotide, Sex Factors, Haplotypes, Risk Factors, Estrogen Receptor beta, Humans, Female, Visual Fields, Algorithms, Glaucoma, Open-Angle, Aged, Netherlands
Male, Optic Disk, Estrogen Receptor alpha, Vision Disorders, Middle Aged, Polymorphism, Single Nucleotide, Sex Factors, Haplotypes, Risk Factors, Estrogen Receptor beta, Humans, Female, Visual Fields, Algorithms, Glaucoma, Open-Angle, Aged, Netherlands
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