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PubMed Central
Other literature type . 2022
License: http://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial-Share Alike 4.0 International Creative Commons License.
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Molecular Biology of the Cell
Article . 2022 . Peer-reviewed
Data sources: Crossref
Molecular Biology of the Cell
Article . 2022
Data sources: Europe PubMed Central
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Effects of Alexander disease–associated mutations on the assembly and organization of GFAP intermediate filaments

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Jul 2022 English Publisher:American Society for Cell Biology (ASCB)Journal:Molecular Biology of the Cell, volume 33 (issn: 1059-1524, eissn: 1939-4586, Copyright policy )
Authors: Yang, Ai-Wen; Lin, Ni-Hsuan; Yeh, Ting-Hung; Snider, Natasha; Perng, Ming-Der;

doi: 10.1091/mbc.e22-01-0013

pmid: 35511821

pmc: PMC9635275

Effects of Alexander disease–associated mutations on the assembly and organization of GFAP intermediate filaments

Abstract

The effects of the GFAP rod end mutations are dominant, changing the assembly process in a way that promotes GFAP aggregation and decreases GFAP solubility. Using Alexander disease brain tissues, clinically relevant evidence is provided that links GFAP assembly defects to disease pathology at the tissue level.

Related Organizations
Keywords

Astrocytes, Glial Fibrillary Acidic Protein, Mutation, Intermediate Filaments, Humans, Articles, Alexander Disease

  • BIP!
    Impact byBIP!
    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 11
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
Powered by OpenAIRE graph
citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
11
Top 10%
Average
Top 10%
Green