Absence of interleukin-1 receptor 1 increases excitatory and inhibitory scaffolding protein expression and microglial activation in the adult mouse hippocampus
Copyright policy )Absence of interleukin-1 receptor 1 increases excitatory and inhibitory scaffolding protein expression and microglial activation in the adult mouse hippocampus
In the present study, we demonstrate that adult mice lacking interleukin-1 receptor 1 (IL-1R1) exhibit increased expression of both the excitatory scaffolding protein postsynaptic density-95 (PSD-95) and inhibitory scaffolding proteingephyrin, respectively, in the hippocampus. The morphology of hippocampal microglia is also altered towards a more activated phenotype. These results indicate an important role for IL-1 signaling in maintaining physiological conditions in both neurons and microglia.
- Lund University Sweden
Cell Nucleus, Mice, Knockout, Aging, Membrane Proteins, Receptors, Interleukin-1, Hippocampus, Animals, Microglia, Carrier Proteins, Disks Large Homolog 4 Protein, Guanylate Kinases, Signal Transduction
Cell Nucleus, Mice, Knockout, Aging, Membrane Proteins, Receptors, Interleukin-1, Hippocampus, Animals, Microglia, Carrier Proteins, Disks Large Homolog 4 Protein, Guanylate Kinases, Signal Transduction
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).11 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!