The Notch Transcription Activation Complex Makes Its Move
Copyright policy )The Notch Transcription Activation Complex Makes Its Move
Two papers in this issue of Cell, (Nam et al., 2006; Wilson and Kovall, 2006) report the crystal structure of the Notch transcriptional activation complex. These structures show that the ANK domain of Notch is an integral part of the transcription complex and supports MAM binding, whereas the RAM domain may trigger allosteric changes in the structure needed for the derepression of transcription.
- University of Mary United States
- Johns Hopkins University United States
- Washington University in St. Louis United States
Models, Molecular, Transcriptional Activation, Receptors, Notch, Transcription, Genetic, Biochemistry, Genetics and Molecular Biology(all), Macromolecular Substances, Protein Conformation, Allosteric Regulation, Animals, Humans, Protein Binding
Models, Molecular, Transcriptional Activation, Receptors, Notch, Transcription, Genetic, Biochemistry, Genetics and Molecular Biology(all), Macromolecular Substances, Protein Conformation, Allosteric Regulation, Animals, Humans, Protein Binding
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