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Human leukocyte antigen class I and II alleles in non-Hodgkin lymphoma etiology

descriptionPublicationkeyboard_double_arrow_right Article 10 Jun 2010 English Publisher:American Society of HematologyJournal:Blood, volume 115, pages 4,820-4,823 (issn: 0006-4971, eissn: 1528-0020,

Authors: Nathaniel Rothman; Mary Carrington; Mary Carrington; Leslie Bernstein; Wendy Cozen; Xiaojiang Gao; Scott Davis; +7 Authors

doi: 10.1182/blood-2010-01-266775

pmid: 20385791

pmc: PMC2890176

Human leukocyte antigen class I and II alleles in non-Hodgkin lymphoma etiology

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Abstract

AbstractGenome-wide association and candidate gene studies implicate different genetic variants within the 6p21 chromosomal region with different non-Hodgkin lymphoma (NHL) subtypes. Complementing these efforts, we conducted human leukocyte antigen (HLA) class I and class II genotyping among 610 NHL cases and 555 controls of non-Hispanic white descent from a US multicenter study. Allele-disease associations were assessed by logistic regression for NHL and its subtypes. Statistically significant associations between HLA and NHL subtypes include HLA-DRB1*0101 for follicular lymphoma (odds ratio [OR] = 2.14, P < .001), HLA-DRB1*0401 for diffuse large B-cell lymphoma (DLBCL; OR = 0.45, P = .006), and HLA-DRB1*13 and follicular lymphoma (OR = 0.48, P = .008). We further observed significant heterozygote advantage for HLA class I alleles and NHL, and particularly DLBCL (P trend = .01 for elevated risk with increasing number of homozygous alleles). Our results support a role for HLA in the etiology of NHL and its subtypes.

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Keywords

Adult, Male, Heterozygote, Lymphoma, Non-Hodgkin, Histocompatibility Antigens Class I, Histocompatibility Antigens Class II, Middle Aged, Humans, Female, Alleles, Aged, Genome-Wide Association Study, Retrospective Studies

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	70
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%