Cladosporium Avr2 Inhibits Tomato Rcr3 Protease Required for Cf-2 -Dependent Disease Resistance
Copyright policy )Cladosporium Avr2 Inhibits Tomato Rcr3 Protease Required for Cf-2 -Dependent Disease Resistance
How plants recognize pathogens and activate defense is still mysterious. Direct interaction between pathogen avirulence (Avr) proteins and plant disease resistance proteins is the exception rather than the rule. During infection, Cladosporium fulvum secretes Avr2 protein into the apoplast of tomato leaves and, in the presence of the extracellular leucine-rich repeat receptor-like Cf-2 protein, triggers a hypersensitive response (HR) that also requires the extracellular tomato cysteine protease Rcr3. We show here that Avr2 binds and inhibits Rcr3 and propose that the Rcr3-Avr2 complex enables the Cf-2 protein to activate an HR.
- Wageningen University & Research Netherlands
- John Innes Centre United Kingdom
- Sainsbury Laboratory United Kingdom
Nicotiana, rin4, Recombinant Fusion Proteins, Biotin, Cysteine Proteinase Inhibitors, Pichia, Fungal Proteins, for-gene concept, Solanum lycopersicum, Leucine, avrrpt2, cysteine protease, Immunoprecipitation, Plant Diseases, Plant Proteins, plants, Extracellular Fluid, Hydrogen-Ion Concentration, proteins, Plant Leaves, arabidopsis, Cysteine Endopeptidases, avirulence gene, fulvum, iii effector, Cladosporium
Nicotiana, rin4, Recombinant Fusion Proteins, Biotin, Cysteine Proteinase Inhibitors, Pichia, Fungal Proteins, for-gene concept, Solanum lycopersicum, Leucine, avrrpt2, cysteine protease, Immunoprecipitation, Plant Diseases, Plant Proteins, plants, Extracellular Fluid, Hydrogen-Ion Concentration, proteins, Plant Leaves, arabidopsis, Cysteine Endopeptidases, avirulence gene, fulvum, iii effector, Cladosporium
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