ABL-kinase domain point mutation as a cause of imatinib (STI571) resistance in CML patient who progress to myeloid blast crisis
Copyright policy )ABL-kinase domain point mutation as a cause of imatinib (STI571) resistance in CML patient who progress to myeloid blast crisis
Imatinib mesylate (STI571) is a major therapeutic advance for the management of chronic myeloid leukaemia (CML), however, a proportion of patients are refractory to it, particularly those in more advanced phases of CML. Different mechanisms of resistance to imatinib are suggested, including point mutations within ABL-kinase domains. A point mutation leading to substitution at the ATP binding site of ABL-kinase and insensitivity to imatinib was detected in our patient treated with imatinib, who progressed to blast crisis. Additionally, clonal evolution could lead to BCR-ABL-independent proliferation. Early detection of ABL-kinase mutation could predict the progression of CML treated with imatinib.
- Jagiellonian University Poland
- Medizinische Fakultät Mannheim Germany
- Heidelberg University Germany
- Jagiellonian University Medical College Poland
Adult, Male, Molecular Sequence Data, Fusion Proteins, bcr-abl, chronic myelogenous leukaemia, Piperazines, resistance, Adenosine Triphosphate, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Sequence Homology, Nucleic Acid, Humans, Point Mutation, Amino Acid Sequence, Proto-Oncogene Proteins c-abl, BCR-ABL, Base Sequence, blast crisis, ABL mutation, Pyrimidines, imatinib, Drug Resistance, Neoplasm, Karyotyping, Benzamides, Imatinib Mesylate, Blast Crisis
Adult, Male, Molecular Sequence Data, Fusion Proteins, bcr-abl, chronic myelogenous leukaemia, Piperazines, resistance, Adenosine Triphosphate, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Sequence Homology, Nucleic Acid, Humans, Point Mutation, Amino Acid Sequence, Proto-Oncogene Proteins c-abl, BCR-ABL, Base Sequence, blast crisis, ABL mutation, Pyrimidines, imatinib, Drug Resistance, Neoplasm, Karyotyping, Benzamides, Imatinib Mesylate, Blast Crisis
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