Variation in Genes of β-glucan Recognition Pathway and Susceptibility to Opportunistic Infections in HIV-Positive Patients
Copyright policy )Variation in Genes of β-glucan Recognition Pathway and Susceptibility to Opportunistic Infections in HIV-Positive Patients
Opportunistic infections are the main cause of morbidity and death among HIV-positive patients. Most of these infections are linked to the immunodeficiency due to low CD4+ counts. However, not all patients with low CD4+ counts are equally susceptible to infections, and we hypothesize that variability in genes of innate immunity may also play an important role. The dectin-1/CARD9 pathway is crucial for recognition of both fungal and bacterial pathogens. The aim of this study was to assess the possible association between the occurrence of opportunistic infections and single nucleotide polymorphisms in DECTIN-1 and CARD9 in a cohort of 187 HIV-infected patients. The incidence of oropharyngeal candidiasis and other opportunistic infections was not influenced by either the Y238X DECTIN-1 or the S12N CARD9 polymorphism. Surprisingly however, the prevalence of pneumonia was significantly higher in patients bearing the defective variant DECTIN-1 allele. These results suggest a role of dectin-1 in the host defense against respiratory bacterial infections, and future studies are warranted to confirm this association.
- National and Kapodistrian University of Athens Greece
- Radboud University Nijmegen Netherlands
- Radboud University Nijmegen Medical Centre Netherlands
Adult, Male, AIDS-Related Opportunistic Infections, Incidence, Genetic Variation, Middle Aged, Polymorphism, Single Nucleotide, Immunity, Innate, CARD Signaling Adaptor Proteins, Cohort Studies, Candidiasis, Oral, HIV Seropositivity, Humans, NCMLS 7: Chemical and physical biology, Female, Genetic Predisposition to Disease, Lectins, C-Type, N4i 2: Invasive mycoses and compromised host NCMLS 1: Infection and autoimmunity
Adult, Male, AIDS-Related Opportunistic Infections, Incidence, Genetic Variation, Middle Aged, Polymorphism, Single Nucleotide, Immunity, Innate, CARD Signaling Adaptor Proteins, Cohort Studies, Candidiasis, Oral, HIV Seropositivity, Humans, NCMLS 7: Chemical and physical biology, Female, Genetic Predisposition to Disease, Lectins, C-Type, N4i 2: Invasive mycoses and compromised host NCMLS 1: Infection and autoimmunity
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