Gamete Recognition in Mice Depends on the Cleavage Status of an Egg’s Zona Pellucida Protein
Copyright policy )Gamete Recognition in Mice Depends on the Cleavage Status of an Egg’s Zona Pellucida Protein
Getting Gametes Together Despite decades of research, the molecular basis of sperm-egg recognition in mammals remains unresolved. Models in which a glycan ligand in the zona pellucida (ZP) surrounding ovulated eggs binds to a sperm surface receptor have been widely embraced. A more recent model proposes that the cleavage status of a ZP protein, ZP2, renders the structure of the zona matrix either permissive or nonpermissive for sperm binding. Gahlay et al. (p. 216 ) tested predictions of each model by replacing endogenous zona proteins with either a mutant form of ZP2 that could not be cleaved or of ZP3 that lacked O glycan attachment sites. Sperm-egg recognition depended on the cleavage status of ZP2 rather than on glycan ligands released following fertilization.
- National Institute of Health Pakistan
- National Institute of Diabetes and Digestive and Kidney Diseases United States
- National Institutes of Health United States
Male, Membrane Glycoproteins, Acrosome Reaction, Egg Proteins, Mice, Transgenic, Receptors, Cell Surface, Embryo, Mammalian, Ligands, Models, Biological, Exocytosis, Mice, Fertility, Polysaccharides, Fertilization, Cell Adhesion, Animals, Female, Mutant Proteins, Acrosome, Sperm Capacitation
Male, Membrane Glycoproteins, Acrosome Reaction, Egg Proteins, Mice, Transgenic, Receptors, Cell Surface, Embryo, Mammalian, Ligands, Models, Biological, Exocytosis, Mice, Fertility, Polysaccharides, Fertilization, Cell Adhesion, Animals, Female, Mutant Proteins, Acrosome, Sperm Capacitation
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