Drosophilaas a model system to unravel the layers of innate immunity to infection
Copyright policy )Drosophilaas a model system to unravel the layers of innate immunity to infection
SummaryInnate immunity relies entirely upon germ-line encoded receptors, signalling components and effector molecules for the recognition and elimination of invading pathogens. The fruit flyDrosophila melanogasterwith its powerful collection of genetic and genomic tools has been the model of choice to develop ideas about innate immunity and host–pathogen interactions. Here, we review current research in the field, encompassing all layers of defence from the role of the microbiota to systemic immune activation, and attempt to speculate on future directions and open questions.
- University of Oxford United Kingdom
Hemocytes, host defence, QH301-705.5, Fat Body, Microbial Consortia, Review, Phagocytosis, Hemolymph, Animals, Drosophila Proteins, Biology (General), Receptors, Immunologic, innate immunity, Immunity, Mucosal, Serratia marcescens, Melanins, Bacteria, Models, Immunological, drosophila, Immunity, Innate, Intestines, Drosophila melanogaster, Larva, Reactive Oxygen Species, Antimicrobial Cationic Peptides, Signal Transduction
Hemocytes, host defence, QH301-705.5, Fat Body, Microbial Consortia, Review, Phagocytosis, Hemolymph, Animals, Drosophila Proteins, Biology (General), Receptors, Immunologic, innate immunity, Immunity, Mucosal, Serratia marcescens, Melanins, Bacteria, Models, Immunological, drosophila, Immunity, Innate, Intestines, Drosophila melanogaster, Larva, Reactive Oxygen Species, Antimicrobial Cationic Peptides, Signal Transduction
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