SNCA variants are associated with increased risk for multiple system atrophy
Copyright policy )SNCA variants are associated with increased risk for multiple system atrophy
AbstractTo test whether the synucleinopathies Parkinson's disease and multiple system atrophy (MSA) share a common genetic etiology, we performed a candidate single nucleotide polymorphism (SNP) association study of the 384 most associated SNPs in a genome‐wide association study of Parkinson's disease in 413 MSA cases and 3,974 control subjects. The 10 most significant SNPs were then replicated in additional 108 MSA cases and 537 controls. SNPs at the SNCA locus were significantly associated with risk for increased risk for the development of MSA (combined p = 5.5 × 1012; odds ratio 6.2). Ann Neurol 2009;65:610–614
- University of Tübingen Germany
- University College London United Kingdom
- Institut für Humangenetik Germany
- National Institutes of Health United States
- National Institute of Environmental Health Sciences United States
Male, Risk, Gene Frequency, Genotype, Odds Ratio, alpha-Synuclein, Humans, Female, Genetic Predisposition to Disease, Multiple System Atrophy, Polymorphism, Single Nucleotide, Genome-Wide Association Study
Male, Risk, Gene Frequency, Genotype, Odds Ratio, alpha-Synuclein, Humans, Female, Genetic Predisposition to Disease, Multiple System Atrophy, Polymorphism, Single Nucleotide, Genome-Wide Association Study
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).261 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 1% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1%
Citations provided by BIP!Popularity provided by BIP!