Characterization of Pellino2, a substrate of IRAK1 and IRAK4
Copyright policy )Characterization of Pellino2, a substrate of IRAK1 and IRAK4
Interleukin‐1 (IL‐1) receptor‐associated kinases (IRAKs) are central components of Toll/IL‐1 receptor (TIR) signaling pathways. In an attempt to discover novel signal transducers in TIR signaling, we identified human Pellino2 as an interaction partner of IRAK4. Pellino2 interacts with kinase‐active as well as kinase‐inactive IRAK1 and IRAK4. Furthermore, Pellino2 is one of the first substrates identified for IRAK1 and IRAK4. Functional studies using overexpression or RNAi knock‐down of Pellino2 suggest a role of Pellino2 as a scaffolding protein similar to Pellino1. However, unlike Pellino1, Pellino2 does not seem to activate a specific transcription factor, but links TIR signaling to basic cellular processes.
Ubiquitin-Protein Ligases, Genetic Vectors, IRAK, Nuclear Proteins, Saccharomyces cerevisiae, Pellino, Recombinant Proteins, Cell Line, Substrate Specificity, Phosphotransferases (Alcohol Group Acceptor), Interleukin-1 Receptor-Associated Kinases, Genes, Reporter, IL-1 signalling, Humans, Cloning, Molecular, Protein Kinases, Cells, Cultured
Ubiquitin-Protein Ligases, Genetic Vectors, IRAK, Nuclear Proteins, Saccharomyces cerevisiae, Pellino, Recombinant Proteins, Cell Line, Substrate Specificity, Phosphotransferases (Alcohol Group Acceptor), Interleukin-1 Receptor-Associated Kinases, Genes, Reporter, IL-1 signalling, Humans, Cloning, Molecular, Protein Kinases, Cells, Cultured
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