Combination of polymorphic variants in serotonin transporter and monoamine oxidase-A genes may influence the risk for early-onset alcoholism
Copyright policy )Combination of polymorphic variants in serotonin transporter and monoamine oxidase-A genes may influence the risk for early-onset alcoholism
The combinatory effect of polymorphisms in serotonin transporter and monoamine oxidase-A genes on the aetiopathogenesis of alcoholism was investigated in a sample of 714 individuals. Increased frequency of subjects having three 'suspected' genotypes (5-HTTLPR-LL, STin2-1010 and MAO-A 3-repeat allele) was found among type-2 alcoholic patients (P=0.0189). Results highlight serotonergic/genetic contribution to early-onset alcoholism.
- Ruđer Bošković Institute Croatia
Adult, Male, Serotonin Plasma Membrane Transport Proteins, Polymorphism, Genetic, serotonin transporter; monoamine-oxidase; alcoholism subtypes, Genotype, serotonin transporter, Alcoholism, Gene Frequency, monoamine-oxidase, Humans, Genetic Predisposition to Disease, alcoholism subtypes, Age of Onset, Monoamine Oxidase, Alleles
Adult, Male, Serotonin Plasma Membrane Transport Proteins, Polymorphism, Genetic, serotonin transporter; monoamine-oxidase; alcoholism subtypes, Genotype, serotonin transporter, Alcoholism, Gene Frequency, monoamine-oxidase, Humans, Genetic Predisposition to Disease, alcoholism subtypes, Age of Onset, Monoamine Oxidase, Alleles
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