The diversity of the immune response to the A2 domain of human factor VIII
Copyright policy )The diversity of the immune response to the A2 domain of human factor VIII
Key PointsThe Abs to the human fVIII A2 domain in a murine hemophilia A model inhibit fVIIIa and activation of fVIII Epitopes targeted by hemophilia A mouse Abs cover nearly the entire surface of the human fVIII A2 domain
- Emory University United States
- Center for Cancer and Blood Disorders United States
Factor VIII, Swine, Thrombin, Antibodies, Monoclonal, Enzyme-Linked Immunosorbent Assay, Cross Reactions, Hemophilia A, Protein Structure, Tertiary, Disease Models, Animal, Epitopes, Mice, Antibody Specificity, Mutagenesis, Site-Directed, Animals, Humans, Epitope Mapping
Factor VIII, Swine, Thrombin, Antibodies, Monoclonal, Enzyme-Linked Immunosorbent Assay, Cross Reactions, Hemophilia A, Protein Structure, Tertiary, Disease Models, Animal, Epitopes, Mice, Antibody Specificity, Mutagenesis, Site-Directed, Animals, Humans, Epitope Mapping
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