miR‐150 functions as a tumour suppressor in human colorectal cancer by targeting c‐Myb
Copyright policy )miR‐150 functions as a tumour suppressor in human colorectal cancer by targeting c‐Myb
AbstractOur previously published study documented a deregulation of the microRNA miR‐150 in colorectal cancer. Here, we investigated further, in vitro and in vivo, the potential molecular mechanisms underlying the involvement of miR‐150 in colorectal cancer, using the appropriate molecular biological methods. We report that miR‐150 is a key regulator in the tumourigenesis and progression of colorectal cancer, by acting as a tumour suppressor targeting c‐Myb. The current findings suggest that miR‐150 may have important roles in the pathogenesis of colorectal cancer.
- Shanghai Jiao Tong University China (People's Republic of)
- Tongji University China (People's Republic of)
- Shanghai University China (People's Republic of)
Male, Mice, Inbred BALB C, Reverse Transcriptase Polymerase Chain Reaction, Blotting, Western, Mice, Nude, Apoptosis, Original Articles, Flow Cytometry, Real-Time Polymerase Chain Reaction, Xenograft Model Antitumor Assays, Immunoenzyme Techniques, Mice, MicroRNAs, Proto-Oncogene Proteins c-myb, Cell Movement, Tumor Cells, Cultured, Animals, Humans, RNA, Messenger, Colorectal Neoplasms, Cell Proliferation
Male, Mice, Inbred BALB C, Reverse Transcriptase Polymerase Chain Reaction, Blotting, Western, Mice, Nude, Apoptosis, Original Articles, Flow Cytometry, Real-Time Polymerase Chain Reaction, Xenograft Model Antitumor Assays, Immunoenzyme Techniques, Mice, MicroRNAs, Proto-Oncogene Proteins c-myb, Cell Movement, Tumor Cells, Cultured, Animals, Humans, RNA, Messenger, Colorectal Neoplasms, Cell Proliferation
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