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Population genetic data on four STR loci, PAI (CA)n, GpIIIa (CT)n, PLAT (TG)14 (CA)12, and NOS2A (CCTTT)n, in Mediterranean populations

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 2007 France English Publisher:Elsevier BVJournal:Legal Medicine, volume 9, pages 218-220 (issn: 1344-6223,

Authors: Falchi, Alessandra; Piras, Ignazio Stefano; Giovannoni, Laurianne; Moral, Pedro; Vona, Giuseppe; Varesi, Laurent;

doi: 10.1016/j.legalmed.2007.01.001

pmid: 17320454

Population genetic data on four STR loci, PAI (CA)n, GpIIIa (CT)n, PLAT (TG)14 (CA)12, and NOS2A (CCTTT)n, in Mediterranean populations

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Abstract

In the present study, we have analyzed four highly polymorphic regions (STRs) chosen from four candidate genes involved in: (1) Platelet aggregation: alpha subunit of the platelet GpIIb/GpIIIa integrin complex (GpIIIa (CT)n; 17q21.31), (2) Coagulation fibrinolysis: Plasminogen Activator Tissue (PLAT5 (TG)14(TA)12; 8p12-q11.2) and Plasminogen Activator Inhibitor-1 (PAI-1 (CA)n; 7q21.3-q22), (3) Oxidative metabolism: the inducible nitric oxide (NO) synthase (iNOS) gene (NOS2A (CCTTT)n; 17cen-q11.2). Allele frequencies for these four STR loci were investigated in several Mediterranean populations. The population data deviate from the Hardy-Weinberg equilibrium in all populations for GpIIIa (CT)n polymorphism.

Country

France

Related Organizations

Sorbonne University
France
University of Barcelona
Spain
University of Cagliari
Italy
University of Corsica Pascal Paoli
France

Keywords

Chi-Square Distribution, Polymorphism, Genetic, Mediterranean Region, Integrin beta3, Nitric Oxide Synthase Type II, Polymerase Chain Reaction, White People, Genetics, Population, Africa, Northern, Gene Frequency, Italy, Spain, Data Interpretation, Statistical, Tissue Plasminogen Activator, Plasminogen Activator Inhibitor 1, [SDV.GEN.GPO] Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE], Humans, France, Sicily, Alleles, Microsatellite Repeats

14 Research products, page 1 of 2

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