The effect of HS-111, a novel thiazolamine derivative, on apoptosis and angiogenesis of hepatocellular carcinoma cells
Copyright policy )The effect of HS-111, a novel thiazolamine derivative, on apoptosis and angiogenesis of hepatocellular carcinoma cells
Hepatocellular carcinoma (HCC) is one of the most common malignancies, yet there have been no significant advances in effective therapeutics. In this study, HS-111 was synthesized as a novel thiazolamine derivative, N-(5-(2-chlorobenzyl) thiazole-2-yl) benzofuran-2-carboxamide, and its anticancer effect and mechanism were examined in human HCC cells. HS-111 strongly suppressed the growth of HCC cells in a dose-dependent manner. Also, apoptosis by HS-111 was identified by DAPI and TUNEL staining, and the increases of the cleaved caspase-3 were observed. In addition, HS-111 decreased protein expression of hypoxia-inducible factor (HIF-1α) and secretion of vascular endothelial growth factor (VEGF), and inhibited tube formation and the migration of human umbilical vein endothelial cells (HUVECs). These results showed that HS-111 not only inhibited cell growth and angiogenesis, but also induced apoptosis of human HCC cells. We suggest that HS-111 may be a potential candidate for chemotherapy against HCC.
- Inha University Korea (Republic of)
- Korea Advanced Institute of Science and Technology Korea (Republic of)
- Korea Advanced Institute of Science and Technology Korea (Republic of)
- Korean Association Of Science and Technology Studies Korea (Republic of)
Wound Healing, Carcinoma, Hepatocellular, Dose-Response Relationship, Drug, Molecular Structure, Neovascularization, Pathologic, Cell Survival, Blotting, Western, Liver Neoplasms, 610, Angiogenesis Inhibitors, Apoptosis, Enzyme-Linked Immunosorbent Assay, Thiazoles, Cell Line, Tumor, Human Umbilical Vein Endothelial Cells, In Situ Nick-End Labeling, Humans, Benzofurans, Cell Proliferation
Wound Healing, Carcinoma, Hepatocellular, Dose-Response Relationship, Drug, Molecular Structure, Neovascularization, Pathologic, Cell Survival, Blotting, Western, Liver Neoplasms, 610, Angiogenesis Inhibitors, Apoptosis, Enzyme-Linked Immunosorbent Assay, Thiazoles, Cell Line, Tumor, Human Umbilical Vein Endothelial Cells, In Situ Nick-End Labeling, Humans, Benzofurans, Cell Proliferation
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).5 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!