RNase L Amplifies Interferon Signaling by Inducing Protein Kinase R-Mediated Antiviral Stress Granules
Copyright policy )RNase L Amplifies Interferon Signaling by Inducing Protein Kinase R-Mediated Antiviral Stress Granules
Double-stranded RNAs produced during viral infections serve as pathogen-associated molecular patterns (PAMPs) and bind pattern recognition receptors to stimulate IFN production. RNase L is an IFN-regulated endoribonuclease that is activated in virus-infected cells and cleaves single-stranded viral and cellular RNAs. The RNase L-cleaved dsRNAs signal to Rig-like helicases to amplify IFN production. This study identifies a novel role of antiviral stress granules induced by RNase L as an antiviral signaling hub to coordinate the RNA ligands with cognate receptors to mount an effective host response during viral infections.
- Columbia University Medical Center United States
- University System of Ohio United States
- University of Toledo United States
DNA Helicases, Cellular Response to Infection, Interferon-beta, Cytoplasmic Granules, DEAD-box RNA Helicases, eIF-2 Kinase, RNA Recognition Motif Proteins, Cell Line, Tumor, Receptors, Pattern Recognition, Endoribonucleases, Humans, RNA, Viral, Interferons, Poly-ADP-Ribose Binding Proteins, RNA, Double-Stranded, Signal Transduction
DNA Helicases, Cellular Response to Infection, Interferon-beta, Cytoplasmic Granules, DEAD-box RNA Helicases, eIF-2 Kinase, RNA Recognition Motif Proteins, Cell Line, Tumor, Receptors, Pattern Recognition, Endoribonucleases, Humans, RNA, Viral, Interferons, Poly-ADP-Ribose Binding Proteins, RNA, Double-Stranded, Signal Transduction
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