Multiple modes of regulation of the human Ino80 SNF2 ATPase by subunits of the INO80 chromatin-remodeling complex
Copyright policy )Multiple modes of regulation of the human Ino80 SNF2 ATPase by subunits of the INO80 chromatin-remodeling complex
Significance SNF2 family ATPases are ATP-dependent motors with roles in diverse nuclear processes. Regulation of the catalytic activity of SNF2 family ATPases via their associated proteins is a key element determining their functions. Thus, illuminating the mechanisms of action of SNF2 regulatory proteins is a priority of current studies. Here, we show subunits of the human INO80 chromatin-remodeling complex act by different mechanisms: Ies2 activates INO80 catalytic activity, while Ies6 and Arp5 function in nucleosome recognition.
- Stowers Institute for Medical Research United States
- University of Kansas Medical Center United States
- University of Kansas United States
DNA Helicases, Zinc Fingers, Chromatin Assembly and Disassembly, Nucleosomes, DNA-Binding Proteins, Angiopoietin-like Proteins, HEK293 Cells, Multienzyme Complexes, ATPases Associated with Diverse Cellular Activities, Humans, Angiopoietin-Like Protein 6, Angiopoietins, HeLa Cells
DNA Helicases, Zinc Fingers, Chromatin Assembly and Disassembly, Nucleosomes, DNA-Binding Proteins, Angiopoietin-like Proteins, HEK293 Cells, Multienzyme Complexes, ATPases Associated with Diverse Cellular Activities, Humans, Angiopoietin-Like Protein 6, Angiopoietins, HeLa Cells
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