Close Linkage of the Dominant Cataract Mutations (Cat-2) with Idh-1 and Cryge on Mouse Chromosome 1
Copyright policy )Close Linkage of the Dominant Cataract Mutations (Cat-2) with Idh-1 and Cryge on Mouse Chromosome 1
The murine dominant gene Cat-2 was located on chromosome 1 between the loci of fuzzy and leaden. Subsequent linkage analysis revealed one recombinant between Cat-2t and isocitrate dehydrogenase-1, and one between Cat-2t and gamma E-crystallin among 338 offspring in three-point backcrosses. The resulting genetic distance between the loci is 0.3 +/- 0.3 cM. The very close linkage between the Cat-2 and the gamma-crystallin gene cluster together with the finding of reduced gamma-crystallin transcripts in mutant lenses suggest strongly that the gamma-crystallin genes may be candidate genes for the Cat-2 mutations.
Recombination, Genetic, Genetic Linkage, Chromosome Mapping, Crystallins, Cataract, Isocitrate Dehydrogenase, Mice, Mutant Strains, Mice, Mice, Inbred AKR, Gene Expression Regulation, Animals, Crosses, Genetic, Genes, Dominant
Recombination, Genetic, Genetic Linkage, Chromosome Mapping, Crystallins, Cataract, Isocitrate Dehydrogenase, Mice, Mutant Strains, Mice, Mice, Inbred AKR, Gene Expression Regulation, Animals, Crosses, Genetic, Genes, Dominant
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