Reduced expression of FLIPSHORT in bone marrow of low risk myelodysplastic syndrome
Copyright policy )Reduced expression of FLIPSHORT in bone marrow of low risk myelodysplastic syndrome
Apoptosis is dysregulated in patients with myelodysplastic syndrome (MDS) and acute myelogenous leukaemia (AML). FLIP (FLICE (FAS-associated death-domain-like IL-1 beta-converting enzyme)-inhibitory protein) has been described as an anti-apoptotic protein. Here, we characterize the expression level of FLIP(LONG) and FLIP(SHORT) mRNA in bone marrow aspirates from 61 patients diagnosed with MDS or AML. FLIP(SHORT) mRNA expression was significantly lower in low risk MDS, compared to high risk MDS, according to FAB classification (RA/RARS versus RAEB/RAEBt, P=0.0127) and IPSS (low risk/intermediate-1 versus intermediate-2/high risk, P=0.0345). Furthermore, FLIP(SHORT) mRNA expression was significantly lower in low risk MDS, compared to MDS-AML/AML de novo (P=0.0006), according to FAB classification. FLIP(LONG) expression did not differ between these groups. Increased levels of FLIP(SHORT) in RAEB and AML may be related to apoptosis resistance in these diseases and to MDS progression.
- State University of Campinas Brazil
Adult, Aged, 80 and over, Male, Gene Expression Regulation, Leukemic, CASP8 and FADD-Like Apoptosis Regulating Protein, Apoptosis, Middle Aged, Leukemia, Myeloid, Acute, Risk Factors, Myelodysplastic Syndromes, Humans, Female, Apoptosis Regulatory Proteins, Aged
Adult, Aged, 80 and over, Male, Gene Expression Regulation, Leukemic, CASP8 and FADD-Like Apoptosis Regulating Protein, Apoptosis, Middle Aged, Leukemia, Myeloid, Acute, Risk Factors, Myelodysplastic Syndromes, Humans, Female, Apoptosis Regulatory Proteins, Aged
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