The clinical significance of cereblon expression in multiple myeloma
Copyright policy )The clinical significance of cereblon expression in multiple myeloma
Cereblon (CRBN) mediates immunomodulatory drug (IMiD) action in multiple myeloma (MM). We demonstrate here that no patient with very low CRBN expression responded to IMiD plus dexamethasone therapy. In 53 refractory MM patients treated with pomalidomide and dexamethasone, CRBN levels predict for decreased response rates and significant differences in PFS (3.0 vs. 8.9 months, p<0.001) and OS (9.1 vs. 27.2 months, p=0.01) (lowest quartile vs. highest three quartiles). While higher CRBN levels can serve as a surrogate for low risk disease, our study demonstrates that low CRBN expression can predict resistance to IMiD monotherapy and is a predictive biomarker for survival outcomes.
- University of New Mexico Hospital United States
- University of Arkansas at Little Rock United States
- University of Colorado Health United States
- Mayo Clinic United States
- Mayo Clinic United States
Ubiquitin-Protein Ligases, Prognosis, Survival Analysis, Dexamethasone, Thalidomide, Gene Expression Regulation, Neoplastic, Treatment Outcome, Drug Resistance, Neoplasm, Cell Line, Tumor, Antineoplastic Combined Chemotherapy Protocols, Biomarkers, Tumor, Humans, Multiple Myeloma, Adaptor Proteins, Signal Transducing, Peptide Hydrolases
Ubiquitin-Protein Ligases, Prognosis, Survival Analysis, Dexamethasone, Thalidomide, Gene Expression Regulation, Neoplastic, Treatment Outcome, Drug Resistance, Neoplasm, Cell Line, Tumor, Antineoplastic Combined Chemotherapy Protocols, Biomarkers, Tumor, Humans, Multiple Myeloma, Adaptor Proteins, Signal Transducing, Peptide Hydrolases
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