Role of thrombomodulin gene in Indian population with coronary artery disease
Copyright policy )Role of thrombomodulin gene in Indian population with coronary artery disease
Thrombomodulin (TM), a natural anticoagulant have been implicated in the pathogenesis of coronary artery disease (CAD) thus emphasizing its potential role as a biomarker.To investigate the role of the TM genetic variants and soluble TM (sTM) plasma levels in Indian population with CAD.This case-control study involved genotyping of the entire TM gene and sTM levels estimation in 266 subjects.None of the four TM genetic variants identified significantly increased CAD risk in the study population. However, further subgroup analysis revealed that in subjects ≤49 years, C1418T variant (Ala455Val substitution) was significantly associated with CAD.The increased CAD risk in subjects ≤49 years due to TM Ala455Val substitution is a promising finding. Further validation on large Indian cohorts is required in order to screen asymptomatic young subjects for CAD risk and to establish the clinical utility of Ala455Val substitution.
Adult, Male, Base Sequence, Thrombomodulin, Age Factors, India, Coronary Artery Disease, Sequence Analysis, DNA, Middle Aged, Polymorphism, Single Nucleotide, Amino Acid Substitution, Case-Control Studies, Humans, Female, Biomarkers, Genetic Association Studies, Polymorphism, Single-Stranded Conformational
Adult, Male, Base Sequence, Thrombomodulin, Age Factors, India, Coronary Artery Disease, Sequence Analysis, DNA, Middle Aged, Polymorphism, Single Nucleotide, Amino Acid Substitution, Case-Control Studies, Humans, Female, Biomarkers, Genetic Association Studies, Polymorphism, Single-Stranded Conformational
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