CRL4 Complex Regulates Mammalian Oocyte Survival and Reprogramming by Activation of TET Proteins
Copyright policy )CRL4 Complex Regulates Mammalian Oocyte Survival and Reprogramming by Activation of TET Proteins
Ubiquitin Fertility Insurance The female mammal's reproductive lifespan is determined by a pool of ovarian primordial follicles that are generated early in life. Yu et al. (p. 1518 ) found that in mice, the ubiquitin E3 ligase complex CRL4 is essential for oocyte survival within primordial follicles and for development after fertilization. CRL4 binds to and activates an adaptor protein that mediates ubiquitination, but if any component is deleted, the genes required for oocyte maintenance and early embryo development are silenced and the female mice become infertile.
- Zhejiang Ocean University China (People's Republic of)
- Life Sciences Institute United States
- Institute of Zoology China (People's Republic of)
- Chinese Academy of Sciences China (People's Republic of)
Mice, Knockout, Cell Survival, Ovary, Protein Serine-Threonine Kinases, Cellular Reprogramming, Cullin Proteins, Gonadal Dysgenesis, Dioxygenases, Mixed Function Oxygenases, DNA-Binding Proteins, Mice, Fertility, Proto-Oncogene Proteins, Oocytes, Animals, Humans, Female, Gene Silencing, Carrier Proteins, HeLa Cells
Mice, Knockout, Cell Survival, Ovary, Protein Serine-Threonine Kinases, Cellular Reprogramming, Cullin Proteins, Gonadal Dysgenesis, Dioxygenases, Mixed Function Oxygenases, DNA-Binding Proteins, Mice, Fertility, Proto-Oncogene Proteins, Oocytes, Animals, Humans, Female, Gene Silencing, Carrier Proteins, HeLa Cells
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