Individual HLA-A, -B, -C, and -DRB1 Genotypes Are No Major Factors Which Determine COVID-19 Severity
Copyright policy )Individual HLA-A, -B, -C, and -DRB1 Genotypes Are No Major Factors Which Determine COVID-19 Severity
HLA molecules are key restrictive elements to present intracellular antigens at the crossroads of an effective T-cell response against SARS-CoV-2. To determine the impact of the HLA genotype on the severity of SARS-CoV-2 courses, we investigated data from 6,919 infected individuals. HLA-A, -B, and -DRB1 allotypes grouped into HLA supertypes by functional or predicted structural similarities of the peptide-binding grooves did not predict COVID-19 severity. Further, we did not observe a heterozygote advantage or a benefit from HLA diplotypes with more divergent physicochemical peptide-binding properties. Finally, numbers of in silico predicted viral T-cell epitopes did not correlate with the severity of SARS-CoV-2 infections. These findings suggest that the HLA genotype is no major factor determining COVID-19 severity. Moreover, our data suggest that the spike glycoprotein alone may allow for abundant T-cell epitopes to mount robust T-cell responses not limited by the HLA genotype.
- Institut für Immunologie Germany
- University Hospital Carl Gustav Carus Germany
- TU Dresden Germany
- Center for Regenerative Therapies TU Dresden (CRTD) Germany
- University of Alberta Canada
Adult, Male, Genotype, in silico prediction, SARS-CoV-2, Immunology, Histocompatibility Antigens Class I, T-cell epitopes, Histocompatibility Antigens Class II, Epitopes, T-Lymphocyte, RC581-607, Middle Aged, HLA, immunogenetics, Female [MeSH] ; Histocompatibility Antigens Class I/genetics [MeSH] ; Immunology ; Adult [MeSH] ; Histocompatibility Antigens Class II/immunology [MeSH] ; Humans [MeSH] ; immunogenetics ; Computer Simulation [MeSH] ; Middle Aged [MeSH] ; Cross-Sectional Studies [MeSH] ; T-cell epitopes ; Coronavirus Infections/genetics [MeSH] ; Epitopes, T-Lymphocyte/genetics [MeSH] ; Epitopes, T-Lymphocyte/immunology [MeSH] ; Male [MeSH] ; Histocompatibility Antigens Class II/genetics [MeSH] ; HLA ; Histocompatibility Antigens Class I/immunology [MeSH] ; ; Genotype [MeSH] ; Spike Glycoprotein, Coronavirus/immunology [MeSH] ; SARS-CoV-2 [MeSH] ; SARS-CoV-2, Cross-Sectional Studies, Spike Glycoprotein, Coronavirus, Humans, Computer Simulation, Female, Immunologic diseases. Allergy, Coronavirus Infections
Adult, Male, Genotype, in silico prediction, SARS-CoV-2, Immunology, Histocompatibility Antigens Class I, T-cell epitopes, Histocompatibility Antigens Class II, Epitopes, T-Lymphocyte, RC581-607, Middle Aged, HLA, immunogenetics, Female [MeSH] ; Histocompatibility Antigens Class I/genetics [MeSH] ; Immunology ; Adult [MeSH] ; Histocompatibility Antigens Class II/immunology [MeSH] ; Humans [MeSH] ; immunogenetics ; Computer Simulation [MeSH] ; Middle Aged [MeSH] ; Cross-Sectional Studies [MeSH] ; T-cell epitopes ; Coronavirus Infections/genetics [MeSH] ; Epitopes, T-Lymphocyte/genetics [MeSH] ; Epitopes, T-Lymphocyte/immunology [MeSH] ; Male [MeSH] ; Histocompatibility Antigens Class II/genetics [MeSH] ; HLA ; Histocompatibility Antigens Class I/immunology [MeSH] ; ; Genotype [MeSH] ; Spike Glycoprotein, Coronavirus/immunology [MeSH] ; SARS-CoV-2 [MeSH] ; SARS-CoV-2, Cross-Sectional Studies, Spike Glycoprotein, Coronavirus, Humans, Computer Simulation, Female, Immunologic diseases. Allergy, Coronavirus Infections
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