Genetic Determinants of Warfarin Dosing in the Han-Chinese Population
Copyright policy )Genetic Determinants of Warfarin Dosing in the Han-Chinese Population
Warfarin, a widely prescribed oral anticoagulant, is used for the prevention of thromboembolism. Polymorphisms in CYP2C9 and VKORC1 have been shown to be associated with warfarin dose requirements. However, it is likely that other genes could also affect warfarin dose.In this study, we aimed to identify additional genes influencing warfarin dosing in the Han-Chinese population.In this study, we screened for SNPs in 13 genes (VKORC1, CYP2C9, CYP2C18, PROC, APOE, EPHX1, CALU, GGCX, ORM1, ORM2, factor II, factor VII and CYP4F2) and tested their associations with warfarin dosing with univariate and multiple regression analysis.Polymorphisms in the VKORC1 gene have the strongest effects on warfarin dose, followed by CYP2C9*3. In addition, our results showed that CYP2C18, PROC and EPHX1 have small but significant associations with warfarin dose. In multiple regression analysis, PROC and EPHX1 explained 3% of the dose variation. The incorporation of these two genes into warfarin dosing algorithms could improve the accuracy of prediction in the Han-Chinese population.
- China Medical University Taiwan
- Academia Sinica Taiwan
- Chang Gung Memorial Hospital Taiwan
- National Taiwan University Hospital Taiwan
- National Taiwan University of Arts Taiwan
CYP2C9, Male, Han-Chinese, Genotype, Metabolic Clearance Rate, Taiwan, 610, Polymorphism, Single Nucleotide, Mixed Function Oxygenases, Asian People, Gene Frequency, Vitamin K Epoxide Reductases, 616, Humans, pharmacogenetics, Dose-Response Relationship, Drug, Anticoagulants, Middle Aged, warfarin, Cytochrome P-450 CYP2C19, VKORC1, Linear Models, Female, Aryl Hydrocarbon Hydroxylases, Warfarin
CYP2C9, Male, Han-Chinese, Genotype, Metabolic Clearance Rate, Taiwan, 610, Polymorphism, Single Nucleotide, Mixed Function Oxygenases, Asian People, Gene Frequency, Vitamin K Epoxide Reductases, 616, Humans, pharmacogenetics, Dose-Response Relationship, Drug, Anticoagulants, Middle Aged, warfarin, Cytochrome P-450 CYP2C19, VKORC1, Linear Models, Female, Aryl Hydrocarbon Hydroxylases, Warfarin
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).70 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!