Collagen VI protects neurons against Aβ toxicity
Copyright policy )Collagen VI protects neurons against Aβ toxicity
Amyloid-beta (Abeta) peptides, widely presumed to cause Alzheimer's disease, increased mouse neuronal expression of collagen VI through a mechanism involving transforming growth factor signaling. Reduction of collagen VI augmented Abeta neurotoxicity, whereas treatment of neurons with soluble collagen VI blocked the association of Abeta oligomers with neurons, enhanced Abeta aggregation and prevented neurotoxicity. These results identify collagen VI as an important component of the neuronal injury response and demonstrate its neuroprotective potential.
- University of Padua Italy
- University of California System United States
- Stanford University United States
- University of California, San Francisco United States
- National Yang Ming University Taiwan
Neurons, Amyloid beta-Peptides, Mice, Transgenic, Collagen Type VI, Nervous system; Extracellular matrix; Neurodegeneration, Peptide Fragments, Mice, Alzheimer Disease, Transforming Growth Factor beta, Astrocytes, Dentate Gyrus, Animals, Humans, Oligonucleotide Array Sequence Analysis, Protein Binding, Signal Transduction
Neurons, Amyloid beta-Peptides, Mice, Transgenic, Collagen Type VI, Nervous system; Extracellular matrix; Neurodegeneration, Peptide Fragments, Mice, Alzheimer Disease, Transforming Growth Factor beta, Astrocytes, Dentate Gyrus, Animals, Humans, Oligonucleotide Array Sequence Analysis, Protein Binding, Signal Transduction
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