Hendra Virus V Protein Inhibits Interferon Signaling by Preventing STAT1 and STAT2 Nuclear Accumulation
Copyright policy )Hendra Virus V Protein Inhibits Interferon Signaling by Preventing STAT1 and STAT2 Nuclear Accumulation
ABSTRACT The V protein of the recently emerged paramyxovirus, Nipah virus, has been shown to inhibit interferon (IFN) signal transduction through cytoplasmic sequestration of cellular STAT1 and STAT2 in high-molecular-weight complexes. Here we demonstrate that the closely related Hendra virus V protein also inhibits cellular responses to IFN through binding and cytoplasmic sequestration of both STAT1 and STAT2, but not STAT3. These findings demonstrate a V protein-mediated IFN signal evasion mechanism that is a general property of the known Henipavirus species.
- Australian Animal Health Laboratory Australia
- Commonwealth Scientific and Industrial Research Organisation Australia
- Icahn School of Medicine at Mount Sinai United States
Cell Nucleus, Molecular Sequence Data, Interferon-alpha, STAT2 Transcription Factor, Cell Line, DNA-Binding Proteins, Interferon-gamma, Viral Proteins, STAT1 Transcription Factor, Trans-Activators, Humans, Amino Acid Sequence, Signal Transduction
Cell Nucleus, Molecular Sequence Data, Interferon-alpha, STAT2 Transcription Factor, Cell Line, DNA-Binding Proteins, Interferon-gamma, Viral Proteins, STAT1 Transcription Factor, Trans-Activators, Humans, Amino Acid Sequence, Signal Transduction
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