Effect of the mouse scid mutation on meiotic recombination
Copyright policy )Effect of the mouse scid mutation on meiotic recombination
The goal of this study was to determine the effect of the mouse severe combined immunodeficiency (scid) mutation on the rate of meiotic recombination, by standard backcross linkage analysis. For this purpose, we examined four crosses that involved F1 hybrid animals heterozygous for the strain C57BL/6 and BALB/c genomes. In one set of reciprocal crosses, F1 animals were homozygous scid/scid, and in a second set of reciprocal crosses, F1 mice were homozygous wild-type (+/+) at the scid locus. Backcross progeny were typed for recombination between selected genetic markers on mouse Chromosomes (Chrs) 1, 4, 6, 7, 9, 15, and 17. Although some differences in recombination were observed over some intervals, the expression of the SCID phenotype did not appear to have a major or consistent effect on meiotic recombination.
- Rutgers, The State University of New Jersey United States
- Jackson Laboratory United States
Genetic Markers, Male, Polymerase-Chain-Reaction, Genotype, Genetic Linkage, 610, Mice, SCID, Mice-Inbred-BALB-C, DNA, Satellite, Polymerase Chain Reaction, 630, Recombination-Genetic, Linkage-(Genetics), Mice, SUPPORT-U-S-GOVT-P-H-S, Animals, Isoenzymes: an, SUPPORT-NON-U-S-GOVT, Crosses, Genetic, Recombination, Genetic, Mice, Inbred BALB C, ge, Genetic-Markers, Mice-Inbred-C57BL, Chromosome Mapping, Crosses-Genetic, DNA-Satellite: an, Isoenzymes, Mice, Inbred C57BL, Mice-SCID: ge, Meiosis, Chromosome-Mapping, Female
Genetic Markers, Male, Polymerase-Chain-Reaction, Genotype, Genetic Linkage, 610, Mice, SCID, Mice-Inbred-BALB-C, DNA, Satellite, Polymerase Chain Reaction, 630, Recombination-Genetic, Linkage-(Genetics), Mice, SUPPORT-U-S-GOVT-P-H-S, Animals, Isoenzymes: an, SUPPORT-NON-U-S-GOVT, Crosses, Genetic, Recombination, Genetic, Mice, Inbred BALB C, ge, Genetic-Markers, Mice-Inbred-C57BL, Chromosome Mapping, Crosses-Genetic, DNA-Satellite: an, Isoenzymes, Mice, Inbred C57BL, Mice-SCID: ge, Meiosis, Chromosome-Mapping, Female
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