Curcumin inhibits hepatitis C virus replication via suppressing the Akt‐SREBP‐1 pathway
Copyright policy )Curcumin inhibits hepatitis C virus replication via suppressing the Akt‐SREBP‐1 pathway
A polyphenolic compound from the curry spice turmeric, curcumin, is known to show anti‐viral activity against the influenza virus, adenovirus, coxsackievirus, and the human immunodeficiency virus. However, it remains to be determined whether curcumin can inhibit the replication of hepatitis C virus (HCV). In this study, we showed that curcumin decreases HCV gene expression via suppression of the Akt‐SREBP‐1 activation, not by NF‐κB pathway. The combination of curcumin and IFNα exerted profound inhibitory effects on HCV replication. Collectively, our results indicate that curcumin can suppress HCV replication in vitro and may be potentially useful as novel anti‐HCV reagents.
- Kunsan National University Korea (Republic of)
- UPRRP College of Natural Sciences Puerto Rico
- Institute of Science Tokyo Japan
- Pusan National University Korea (Republic of)
Gene Expression Regulation, Viral, Curcumin, Hepacivirus, Viral Nonstructural Proteins, NS5A, Virus Replication, Antiviral Agents, Phosphatidylinositol 3-Kinases, Cell Line, Tumor, Humans, SREBP-1, Reverse Transcriptase Polymerase Chain Reaction, Akt, Anti-Inflammatory Agents, Non-Steroidal, NF-kappa B, Transcription Factor RelA, Interferon-alpha, Drug Synergism, HCV, RNA Interference, Sterol Regulatory Element Binding Protein 1, Proto-Oncogene Proteins c-akt, Signal Transduction
Gene Expression Regulation, Viral, Curcumin, Hepacivirus, Viral Nonstructural Proteins, NS5A, Virus Replication, Antiviral Agents, Phosphatidylinositol 3-Kinases, Cell Line, Tumor, Humans, SREBP-1, Reverse Transcriptase Polymerase Chain Reaction, Akt, Anti-Inflammatory Agents, Non-Steroidal, NF-kappa B, Transcription Factor RelA, Interferon-alpha, Drug Synergism, HCV, RNA Interference, Sterol Regulatory Element Binding Protein 1, Proto-Oncogene Proteins c-akt, Signal Transduction
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