CRM1 Is an Export Receptor for Leucine-Rich Nuclear Export Signals
Copyright policy )CRM1 Is an Export Receptor for Leucine-Rich Nuclear Export Signals
CRM1 is distantly related to receptors that mediate nuclear protein import and was previously shown to interact with the nuclear pore complex. Overexpression of CRM1 in Xenopus oocytes stimulates Rev and U snRNA export from the nucleus. Conversely, leptomycin B, a cytotoxin that is shown to bind to CRM1 protein, specifically inhibits the nuclear export of Rev and U snRNAs. In vitro, CRM1 forms a leptomycin B-sensitive complex involving cooperative binding of both RanGTP and the nuclear export signal (NES) from either the Rev or PKI proteins. We conclude that CRM1 is an export receptor for leucine-rich nuclear export signals and discuss a model for the role of RanGTP in CRM1 function and in nuclear export in general.
- European Molecular Biology Laboratory Germany
- University of Tokyo Japan
Antifungal Agents, Biochemistry, Genetics and Molecular Biology(all), Xenopus, Nuclear Proteins, Receptors, Cytoplasmic and Nuclear, Biological Transport, Exportin 1 Protein, Karyopherins, Protein Sorting Signals, Fungal Proteins, Gene Products, rev, ran GTP-Binding Protein, GTP-Binding Proteins, Leucine, RNA, Small Nuclear, Fatty Acids, Unsaturated, Oocytes, Animals, Carrier Proteins, Transcription Factors
Antifungal Agents, Biochemistry, Genetics and Molecular Biology(all), Xenopus, Nuclear Proteins, Receptors, Cytoplasmic and Nuclear, Biological Transport, Exportin 1 Protein, Karyopherins, Protein Sorting Signals, Fungal Proteins, Gene Products, rev, ran GTP-Binding Protein, GTP-Binding Proteins, Leucine, RNA, Small Nuclear, Fatty Acids, Unsaturated, Oocytes, Animals, Carrier Proteins, Transcription Factors
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).2K popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 0.1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 0.1% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 0.01%
Citations provided by BIP!Popularity provided by BIP!