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Successful Treatment of Balamuthia mandrillaris Granulomatous Amebic Encephalitis with Nitroxoline

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Jan 2023Publisher:Centers for Disease Control and Prevention (CDC)Journal:Emerging Infectious Diseases, volume 29, pages 197-201 (issn: 1080-6040, eissn: 1080-6059, Copyright policy )
Authors: Natasha Spottiswoode; Douglas Pet; Annie Kim; Katherine Gruenberg; Maulik Shah; Amrutha Ramachandran; Matthew T. Laurie; +11 Authors

doi: 10.3201/eid2901.221531

pmid: 36573629

pmc: PMC9796214

Successful Treatment of Balamuthia mandrillaris Granulomatous Amebic Encephalitis with Nitroxoline

Abstract

A patient in California, USA, with rare and usually fatal Balamuthia mandrillaris granulomatous amebic encephalitis survived after receiving treatment with a regimen that included the repurposed drug nitroxoline. Nitroxoline, which is a quinolone typically used to treat urinary tract infections, was identified in a screen for drugs with amebicidal activity against Balamuthia.

Related Organizations
Keywords

Infectious Encephalitis, Granuloma, ameba drug effects, R, Dispatch, Brain, Infectious and parasitic diseases, RC109-216, Amebiasis, Balamuthia mandrillaris, nitroxoline, Infectious encephalitis, granulomatous amebic encephalitis, ameba, Medicine, Humans

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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
32
Top 10%
Top 10%
Top 10%
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