Expression of AP-2α, AP-2γ and ESDN in primary melanomas: Correlation with histopathological features and potential prognostic value
Copyright policy )Expression of AP-2α, AP-2γ and ESDN in primary melanomas: Correlation with histopathological features and potential prognostic value
Melanoma is characterized by increasing trends of incidence and high metastatic potential. The transition from non-invasive to invasive and metastatic stage is characterized by a multi-step process by which tumour cells acquire the ability to detach and invade adjacent tissues. Loss of the transcription factor activator protein-2α (AP-2α) is an important molecular event in melanoma progression resulting in deregulation of AP-2 target genes involved in tumour growth and metastasis and associated with short Disease-Free-Survival (DFS)
Skin Neoplasms, Prognosi, 610, DFS, Biochemistry, Biomarkers, Tumor, Humans, Neoplasm Invasiveness, Skin Neoplasm, Membrane Protein, Molecular Biology, Melanoma, Neoplasm Invasivene, Tumor, AP-2alpha, Membrane Proteins, Prognosis, Immunohistochemistry, ESDN, Transcription Factor AP-2, Biomarkers, AP-2gamma, Human, 2708
Skin Neoplasms, Prognosi, 610, DFS, Biochemistry, Biomarkers, Tumor, Humans, Neoplasm Invasiveness, Skin Neoplasm, Membrane Protein, Molecular Biology, Melanoma, Neoplasm Invasivene, Tumor, AP-2alpha, Membrane Proteins, Prognosis, Immunohistochemistry, ESDN, Transcription Factor AP-2, Biomarkers, AP-2gamma, Human, 2708
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