The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells
Copyright policy )The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells
Regulatory T cells (T(reg) cells) are required for peripheral tolerance. Evidence indicates that T(reg) cells can adopt specialized differentiation programs in the periphery that are controlled by transcription factors usually associated with helper T cell differentiation. Here we demonstrate that expression of the transcription factor Blimp-1 defined a population of T(reg) cells that localized mainly to mucosal sites and produced IL-10. Blimp-1 was required for IL-10 production by these cells and for their tissue homeostasis. We provide evidence that the transcription factor IRF4, but not the transcription factor T-bet, was essential for Blimp-1 expression and for the differentiation of all effector T(reg) cells. Thus, our study defines a differentiation pathway that leads to the acquisition of T(reg) cell effector functions and requires both IRF4 and Blimp-1.
- University of Melbourne Australia
- University of Queensland Australia
- Vienna Biocenter Austria
- Walter and Eliza Hall Institute of Medical Research Australia
- Research Institute of Molecular Pathology Austria
570, Green Fluorescent Proteins, Molecular Sequence Data, Mice, Transgenic, Regulatory Sequences, Nucleic Acid, Mice, Animals, Cells, Cultured, Oligonucleotide Array Sequence Analysis, Mice, Knockout, 2403 Immunology, Binding Sites, Base Sequence, Reverse Transcriptase Polymerase Chain Reaction, Gene Expression Profiling, Cell Differentiation, Flow Cytometry, Interleukin-10, Mice, Inbred C57BL, Interferon Regulatory Factors, 2723 Immunology and Allergy, Positive Regulatory Domain I-Binding Factor 1, Protein Binding
570, Green Fluorescent Proteins, Molecular Sequence Data, Mice, Transgenic, Regulatory Sequences, Nucleic Acid, Mice, Animals, Cells, Cultured, Oligonucleotide Array Sequence Analysis, Mice, Knockout, 2403 Immunology, Binding Sites, Base Sequence, Reverse Transcriptase Polymerase Chain Reaction, Gene Expression Profiling, Cell Differentiation, Flow Cytometry, Interleukin-10, Mice, Inbred C57BL, Interferon Regulatory Factors, 2723 Immunology and Allergy, Positive Regulatory Domain I-Binding Factor 1, Protein Binding
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