Three genes for mitochondrial proteins suppress null-mutations in both Afg3 and Rca1 when over-expressed
Copyright policy )Three genes for mitochondrial proteins suppress null-mutations in both Afg3 and Rca1 when over-expressed
The AFG3 gene of Saccharomyces cerevisiae encodes a mitochondrial inner membrane protein with ATP-dependent protease activity. To gain more insight into the function of this protein, multi-copy suppressors of an afg3-null mutation were isolated. Three genes were found that restored partial growth on non-fermentable carbon sources, all of which affect the biogenesis of respiratory competent mitochondria: PIM1(LON) encodes a matrix-localized ATP-dependent protease involved in the turnover of matrix proteins; OXA1(PET1402) encodes a putative mitochondrial inner membrane protein involved in the biogenesis of the respiratory chain; and MBA1 encodes a mitochondrial protein required for optimal respiratory growth. All three genes also suppressed a null mutation in a related gene, RCA1, as well as in the combination of afg3- and rca1-null.
- University of Amsterdam Netherlands
Adenosine Triphosphatases, Cell Nucleus, 570, Genomic Library, Saccharomyces cerevisiae Proteins, Genotype, Genes, Fungal, Restriction Mapping, Serine Endopeptidases, Gene Expression, Membrane Proteins, Metalloendopeptidases, Nuclear Proteins, Saccharomyces cerevisiae, DNA, Mitochondrial, Mitochondria, Electron Transport Complex IV, Fungal Proteins, Mitochondrial Proteins, Suppression, Genetic, ATP-Dependent Proteases
Adenosine Triphosphatases, Cell Nucleus, 570, Genomic Library, Saccharomyces cerevisiae Proteins, Genotype, Genes, Fungal, Restriction Mapping, Serine Endopeptidases, Gene Expression, Membrane Proteins, Metalloendopeptidases, Nuclear Proteins, Saccharomyces cerevisiae, DNA, Mitochondrial, Mitochondria, Electron Transport Complex IV, Fungal Proteins, Mitochondrial Proteins, Suppression, Genetic, ATP-Dependent Proteases
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