Functional Polymorphisms of CHRNA3 Predict Risks of Chronic Obstructive Pulmonary Disease and Lung Cancer in Chinese
Copyright policy )Functional Polymorphisms of CHRNA3 Predict Risks of Chronic Obstructive Pulmonary Disease and Lung Cancer in Chinese
Recently, several genome-wide association studies (GWAS) have identified many susceptible single nucleotide polymorphisms (SNPs) for chronic obstructive pulmonary disease (COPD) and lung cancer which are two closely related diseases. Among those SNPs, some of them are shared by both the diseases, reflecting there is possible genetic similarity between the diseases. Here we tested the hypothesis that whether those shared SNPs are common predictor for risks or prognosis of COPD and lung cancer. Two SNPs (rs6495309 and rs1051730) located in nicotinic acetylcholine receptor alpha 3 (CHRNA3) gene were genotyped in 1511 patients with COPD, 1559 lung cancer cases and 1677 controls in southern and eastern Chinese populations. We found that the rs6495309CC and rs6495309CT/CC variant genotypes were associated with increased risks of COPD (OR = 1.32, 95% C.I. = 1.14-1.54) and lung cancer (OR = 1.57; 95% CI = 1.31-1.87), respectively. The rs6495309CC genotype contributed to more rapid decline of annual Forced expiratory volume in one second (FEV1) in both COPD cases and controls (PA. The data show a statistical association and suggest biological plausibility that the rs6495309T>C polymorphism contributed to increased risks and poor prognosis of both COPD and lung cancer.
- Duke University United States
- State Key Laboratory of Respiratory Disease China (People's Republic of)
- The University of Texas System United States
- Soochow University China (People's Republic of)
- Sun Yat-sen University China (People's Republic of)
Asian Continental Ancestry Group, Male, Chronic Obstructive, China, Lung Neoplasms, Genotype, Science, 610, Kaplan-Meier Estimate, Receptors, Nicotinic, Nicotinic, Polymorphism, Single Nucleotide, Pulmonary Disease, Pulmonary Disease, Chronic Obstructive, Asian People, Gene Frequency, Risk Factors, Receptors, Humans, Genetic Predisposition to Disease, Polymorphism, Alleles, Q, R, Single Nucleotide, Middle Aged, Prognosis, Respiratory Function Tests, Haplotypes, Case-Control Studies, Linear Models, Medicine, Female, Research Article, Genome-Wide Association Study
Asian Continental Ancestry Group, Male, Chronic Obstructive, China, Lung Neoplasms, Genotype, Science, 610, Kaplan-Meier Estimate, Receptors, Nicotinic, Nicotinic, Polymorphism, Single Nucleotide, Pulmonary Disease, Pulmonary Disease, Chronic Obstructive, Asian People, Gene Frequency, Risk Factors, Receptors, Humans, Genetic Predisposition to Disease, Polymorphism, Alleles, Q, R, Single Nucleotide, Middle Aged, Prognosis, Respiratory Function Tests, Haplotypes, Case-Control Studies, Linear Models, Medicine, Female, Research Article, Genome-Wide Association Study
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