Requirement for Croquemort in Phagocytosis of Apoptotic Cells in Drosophila
Copyright policy )Requirement for Croquemort in Phagocytosis of Apoptotic Cells in Drosophila
Macrophages in the Drosophila embryo are responsible for the phagocytosis of apoptotic cells and are competent to engulf bacteria. Croquemort (CRQ) is a CD36-related receptor expressed exclusively on these macrophages. Genetic evidence showed that crq was essential for efficient phagocytosis of apoptotic corpses but was not required for the engulfment of bacteria. The expression of CRQ was regulated by the amount of apoptosis. These data define distinct pathways for the phagocytosis of corpses and bacteria in Drosophila .
- University of Strasbourg France
- Harvard University United States
- Massachusetts General Hospital United States
- Institute of Genetics and Molecular and Cellular Biology France
- Inserm France
CD36 Antigens, Receptors, Scavenger, Staphylococcus aureus, Embryo, Nonmammalian, Macrophages, Gene Expression Regulation, Developmental, Membrane Proteins, Apoptosis, Genes, Insect, Ion Pumps, Phenotype, Phagocytosis, Escherichia coli, Animals, Drosophila Proteins, Drosophila, Receptors, Immunologic, Carrier Proteins, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, Gene Deletion
CD36 Antigens, Receptors, Scavenger, Staphylococcus aureus, Embryo, Nonmammalian, Macrophages, Gene Expression Regulation, Developmental, Membrane Proteins, Apoptosis, Genes, Insect, Ion Pumps, Phenotype, Phagocytosis, Escherichia coli, Animals, Drosophila Proteins, Drosophila, Receptors, Immunologic, Carrier Proteins, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, Gene Deletion
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