TNF‐α and IL‐4 regulate expression of fractalkine (CX3CL1) as a membrane‐anchored proadhesive protein and soluble chemotactic peptide on human fibroblasts
Copyright policy )TNF‐α and IL‐4 regulate expression of fractalkine (CX3CL1) as a membrane‐anchored proadhesive protein and soluble chemotactic peptide on human fibroblasts
The CX3C chemokine, fractalkine (FKN, CX3CL1), has multiple functions and exists as two distinct forms, a membrane‐anchored protein and a soluble chemotactic peptide that cleaves from the cell surface FKN. In this study, we first demonstrated the expression of FKN in tumor necrosis factor (TNF)‐α‐ and interleukin (IL)‐4‐stimulated human fibroblasts. The induction of FKN was observed for both forms. We also demonstrated monocyte chemotactic activity in the culture supernatant from the fibroblasts stimulated with these cytokines. These results suggest that TNF‐α‐ and IL‐4‐stimulated fibroblasts may play an important role in accumulation of monocytes at inflammatory sites.
Chemokine CX3CL1, Tumor Necrosis Factor-alpha, Chemotaxis, Membrane Proteins, Fibroblasts, Fractalkine, Chemokines, CX3C, Monocytes, CX3CL1, Tumor necrosis factor-α, Gene Expression Regulation, Solubility, Fibroblast, Humans, Interleukin-4, Cell Adhesion Molecules
Chemokine CX3CL1, Tumor Necrosis Factor-alpha, Chemotaxis, Membrane Proteins, Fibroblasts, Fractalkine, Chemokines, CX3C, Monocytes, CX3CL1, Tumor necrosis factor-α, Gene Expression Regulation, Solubility, Fibroblast, Humans, Interleukin-4, Cell Adhesion Molecules
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